Massage therapy significantly reduces the gastric residual volume and vomiting in preterm infants. The mean abdominal circumference (MD = - 1.51 95% CI: - 4.86 to 1.84 P = 0.38) and mean gastric residual number (MD = - 0.05 95% CI: - 0.34 to 0.24 P = 0.74) were lower in the massage therapy group compared to the control group, although not in a statistically significant manner. According to the meta-analysis conducted on 128 preterm infants, the mean gastric residual volume (MD = - 2.11 95% CI: - 2.76 to - 1.45, P < 0.00001) and mean frequency of vomiting (MD = - 0.84 95% CI: - 1.37 to - 0.31 P = 0.002) were significantly lower in the massage therapy group compared to the control group. Of the 528 reviewed articles, eight were eligible for this study and finally six studies were included in the meta-analysis. GRADE approach was used to assess the quality of the evidence. The results of the meta-analysis were reported as mean difference, and the heterogeneity of the studies was evaluated using I 2. The risk of bias in the studies was assessed using the Cochrane guidelines. This systematic review investigates the effect of massage on feeding intolerance in preterm infants.Ī search was carried out in English databases including Medline (via PubMed), Scopus, Cochrane Library, Google Scholar, Embase (via Ovid) and Persian databases including SID and Magiran for articles published until November 2019 with language restrictions (English or Persian) but no time restrictions. Massage therapy is a cost-effective intervention that has a positive impact on the health of infants and their parents. Fish and Wildlife Service, Garra rufa could pose a threat to native plant and animal life if released into the wild because the fish is not native to the United States.Feeding intolerance in premature infants is one of the main causes of their long-term hospitalization in NICUs.
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